Purine nucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAMLD1, STK17A, and DNAH5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAMLD1 grouped by Purine nucleoside diphosphate biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	MAMLD1 →	-1.785	-1.429	.004	<.001	3	5
LIVER	STK17A →	-1.616	-1.247	.002	.002	3	5
LIVER	DNAH5 →	-1.030	-2.007	<.001	<.001	3	5
PANCREAS	FMN1 →	-1.175	-1.283	.007	<.001	3	5
LARGE_INTESTINE	IL6ST →	-0.869	-0.791	.001	<.001	3	5
LARGE_INTESTINE	FJX1 →	-1.761	-0.988	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAMLD1 by Purine nucleoside diphosphate biosynthetic process activity — LIVER

Explore this box plot interactively →