Purine nucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AK4, NFKBIB, and RHOC, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate biosynthetic process activity versus AK4 in BLOOD_Lymphoma (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AK4 →	+2.328	+0.233	<.001	<.001	3	6
BONE	NFKBIB →	-0.918	-0.361	.008	<.001	3	5
BLOOD_Lymphoma	RHOC →	+3.074	+0.329	<.001	<.001	3	5
BLOOD_Lymphoma	TIGD4 →	+0.513	+0.295	<.001	<.001	3	5
BONE	TIMM50 →	-0.890	-0.471	<.001	<.001	3	4
BONE	SPNS1 →	-0.309	-0.304	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009136 vs AK4 — BLOOD_Lymphoma

Explore this scatter interactively →