Purine nucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside diphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GTF2A2, PYCARD, and RHBDF2_S385, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate metabolic process activity versus GTF2A2 in LSCC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GTF2A2 →	-0.369	-0.089	<.001	<.001	3	7
CCRCC	PYCARD →	+0.531	+0.057	<.001	<.001	3	6
LSCC	RHBDF2_S385 →	+0.490	+0.066	<.001	<.001	3	6
GBM	RTCB →	-0.187	-0.074	<.001	<.001	3	6
CCRCC	SP1 →	-0.246	-0.044	.002	.001	3	6
LSCC	SUDS3 →	-0.236	-0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009135 vs GTF2A2 — LSCC

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