Purine nucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAR1AP3, ALG1L15P, and MAGT1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate metabolic process activity versus SAR1AP3 in CCRCC (Pearson r = -0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SAR1AP3 →	-0.408	-0.966	.002	.001	3	3
COAD	ALG1L15P →	-0.285	-0.166	<.001	<.001	3	3
BRCA	MAGT1 →	+0.452	+0.162	.001	<.001	3	3
BRCA	IGSF21 →	+0.876	+0.108	.007	.005	3	3
GBM	AK5 →	+2.150	+0.231	<.001	<.001	3	3
BRCA	FANCA →	-0.669	-0.132	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009135 vs SAR1AP3 — CCRCC

Explore this scatter interactively →