Purine nucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASSF1, TSPAN6, and FUCA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate metabolic process activity versus RASSF1 in SKIN (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RASSF1 →	+0.935	+0.175	<.001	.005	3	6
SKIN	TSPAN6 →	-0.539	-0.202	.004	.001	3	5
BLOOD_Lymphoma	FUCA2 →	+2.192	+0.102	.008	.008	3	5
OVARY	ETHE1 →	+1.153	+0.245	.006	.009	3	5
LUNG_SCLC	ENO2 →	+2.141	+0.200	<.001	<.001	3	5
LUNG_NSCLC_LUSC	CCDC25 →	+0.962	+0.243	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009135 vs RASSF1 — SKIN

Explore this scatter interactively →