Nucleoside diphosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside diphosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BPTF, C12orf43, and CRNKL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside diphosphate catabolic process activity versus BPTF in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BPTF →	-0.462	-0.063	<.001	<.001	3	7
BRCA	C12orf43 →	-0.357	-0.056	<.001	<.001	3	7
BRCA	CRNKL1 →	-0.295	-0.055	<.001	<.001	3	7
BRCA	ESF1 →	-0.291	-0.039	<.001	<.001	3	7
COAD	PDRG1 →	-0.284	-0.041	<.001	<.001	3	6
BRCA	UTP4 →	-0.457	-0.064	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009134 vs BPTF — BRCA

Explore this scatter interactively →