Nucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside diphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMACR, ANLN, and CLCN7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AMACR grouped by Nucleoside diphosphate catabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AMACR →	-1.356	-0.266	.001	<.001	3	6
STOMACH	ANLN →	+1.568	+0.258	.003	.001	2	6
LUNG_NSCLC_LUAD	CLCN7 →	-0.926	-0.435	<.001	.004	3	5
PANCREAS	C2CD4D →	-0.200	-0.235	.003	.004	2	5
BLOOD_Leukemia	MYO15B →	-2.346	-0.279	.004	.003	3	4
UPPER_AERODIGESTIVE_TRACT	MFSD9 →	-1.278	-0.386	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AMACR by Nucleoside diphosphate catabolic process activity — STOMACH

Explore this box plot interactively →