Nucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside diphosphate catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBB, ANKHD1-EIF4EBP3, and RGS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBB grouped by Nucleoside diphosphate catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TUBB →	+0.313	+0.070	.003	<.001	3	5
BLOOD_Leukemia	ANKHD1-EIF4EBP3 →	-0.121	-0.062	.003	.005	3	4
PANCREAS	RGS3 →	+0.371	+0.107	.001	<.001	3	4
LIVER	ACVR1B →	-0.186	-0.089	.003	.003	3	4
LIVER	SULT1C2 →	+0.151	+0.107	.001	<.001	3	4
LIVER	TWF2 →	+0.262	+0.122	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBB by Nucleoside diphosphate catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →