Nucleoside diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside diphosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP14_S33, IFIH1, and MCM3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside diphosphate biosynthetic process activity versus PARP14_S33 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PARP14_S33 →	+0.892	+0.048	<.001	.002	3	8
BRCA	IFIH1 →	+0.634	+0.042	.001	.003	3	7
UCEC	MCM3 →	+0.571	+0.064	<.001	.002	3	7
LUAD	NOP16 →	+0.461	+0.066	<.001	<.001	3	7
BRCA	CMPK2 →	+0.575	+0.041	<.001	.004	3	7
GBM	DDX58 →	+0.615	+0.069	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009133 vs PARP14_S33 — BRCA

Explore this scatter interactively →