Nucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MN1, PTTG1IP, and XRCC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MN1 grouped by Nucleoside diphosphate biosynthetic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MN1 →	-1.385	-0.217	.007	.007	2	5
LARGE_INTESTINE	PTTG1IP →	-0.910	-0.376	.004	<.001	3	4
LARGE_INTESTINE	XRCC5 →	-0.491	-0.257	<.001	.001	3	4
KIDNEY	TNS1 →	-1.832	-0.754	.002	.004	3	4
UPPER_AERODIGESTIVE_TRACT	TTLL7 →	-1.225	-0.297	.004	.002	3	3
UPPER_AERODIGESTIVE_TRACT	CARD14 →	+1.826	+0.265	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MN1 by Nucleoside diphosphate biosynthetic process activity — OESOPHAGUS

Explore this box plot interactively →