Nucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB3A, DBR1, and C17orf58, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside diphosphate biosynthetic process activity versus RAB3A in BONE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RAB3A →	+1.302	+0.482	.006	.003	3	8
BONE	DBR1 →	+0.685	+0.402	<.001	<.001	3	6
BLOOD_Lymphoma	C17orf58 →	+0.953	+0.186	.005	.003	3	6
LIVER	LETM1 →	+1.141	+0.217	<.001	.001	3	6
OVARY	UBIAD1 →	+0.702	+0.178	.001	.009	3	6
STOMACH	RPL4 →	+0.765	+0.339	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009133 vs RAB3A — BONE

Explore this scatter interactively →