Nucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside diphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MX2, SIGLEC1, and XRCC5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside diphosphate metabolic process activity versus MX2 in GBM (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MX2 →	+0.759	+0.043	<.001	<.001	3	8
OV	SIGLEC1 →	+0.376	+0.025	.007	.008	3	7
GBM	XRCC5 →	-0.392	-0.062	<.001	<.001	3	7
HNSC	IFIT3 →	+0.816	+0.048	.004	.003	3	7
PDAC	SPIN1_S199 →	-0.622	-0.033	.003	.001	3	7
GBM	SUDS3 →	-0.326	-0.045	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009132 vs MX2 — GBM

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