Nucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside diphosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRM2, RRM1, and CAD, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRM2 grouped by Nucleoside diphosphate metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RRM2 →	-0.468	-0.310	<.001	<.001	3	9
LIVER	RRM1 →	-0.612	-0.415	.002	<.001	2	6
UPPER_AERODIGESTIVE_TRACT	CAD →	-0.306	-0.189	.002	.009	2	6
URINARY_TRACT	RAD17 →	-0.267	-0.195	.005	.004	3	5
LUNG_NSCLC_LUAD	TBC1D3D →	-0.163	-0.201	.001	.002	3	4
PANCREAS	PCYT1A →	+0.153	+0.183	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRM2 by Nucleoside diphosphate metabolic process activity — CNS

Explore this box plot interactively →