Nucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SULT1A1, TNIP1, and PRODH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SULT1A1 grouped by Nucleoside diphosphate metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SULT1A1 →	-2.624	-0.143	.003	.002	3	5
LUNG_SCLC	TNIP1 →	+1.679	+0.247	.006	<.001	3	5
SKIN	PRODH →	-1.525	-0.226	<.001	<.001	3	5
SKIN	EXOG →	+0.869	+0.296	<.001	<.001	3	4
LUNG_NSCLC_LUSC	THOC7 →	+0.394	+0.214	<.001	<.001	3	4
LUNG_NSCLC_LUSC	GLRX →	+2.801	+0.274	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SULT1A1 by Nucleoside diphosphate metabolic process activity — KIDNEY

Explore this box plot interactively →