Pyrimidine nucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF18A, PRPS2, and GRP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate biosynthetic process activity versus KIF18A in BRCA (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KIF18A →	+0.733	+0.193	<.001	<.001	3	5
LUAD	PRPS2 →	+0.329	+0.107	.003	.009	3	4
BRCA	GRP →	-1.470	-0.209	<.001	.001	3	4
LSCC	STK26 →	+0.619	+0.158	.001	.002	3	4
BRCA	MYBL2 →	+0.954	+0.134	<.001	.001	3	4
BRCA	TCF19 →	+0.706	+0.158	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009130 vs KIF18A — BRCA

Explore this scatter interactively →