Pyrimidine nucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF9, KIF18B, and TMEM106A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate metabolic process activity versus TNFRSF9 in LUAD (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TNFRSF9 →	+0.666	+0.198	<.001	<.001	3	6
BRCA	KIF18B →	+0.824	+0.185	<.001	<.001	3	5
LUAD	TMEM106A →	+0.423	+0.172	<.001	<.001	3	5
LUAD	PTPRN2 →	-1.015	-0.238	<.001	<.001	3	5
LUAD	CSF1 →	+0.955	+0.218	<.001	<.001	2	6
GBM	VSIG2 →	-0.335	-0.132	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009129 vs TNFRSF9 — LUAD

Explore this scatter interactively →