Pyrimidine nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside monophosphate metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYMS, CAD, and CMPK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TYMS grouped by Pyrimidine nucleoside monophosphate metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TYMS →	-0.675	-0.865	<.001	.009	3	9
BREAST	CAD →	-0.496	-1.133	<.001	<.001	3	7
SKIN	CMPK1 →	-0.428	-1.263	.004	.001	3	6
OVARY	DUT →	-0.333	-1.108	.004	.004	3	5
LUNG_NSCLC_LUAD	SPDYE7P →	+0.186	+1.085	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	C1QA →	+0.140	+1.082	.007	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TYMS by Pyrimidine nucleoside monophosphate metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →