Pyrimidine nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCM2, SHMT1, and UCK1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate metabolic process activity versus MCM2 in BONE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MCM2 →	+1.579	+0.135	.006	.001	3	14
BONE	SHMT1 →	+1.599	+0.148	<.001	<.001	3	14
SOFT_TISSUE	UCK1 →	+0.944	+0.107	<.001	<.001	3	13
BREAST	KNSTRN →	+0.858	+0.086	<.001	<.001	3	13
LUNG_NSCLC_LUSC	TCOF1 →	+1.032	+0.106	.001	.001	3	13
OESOPHAGUS	POLQ →	+1.246	+0.113	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009129 vs MCM2 — BONE

Explore this scatter interactively →