Purine nucleoside monophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD6, ZBED2, and SLC7A7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate catabolic process activity versus CARD6 in GBM (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CARD6 →	+0.807	+0.153	<.001	<.001	3	6
COAD	ZBED2 →	+0.672	+0.149	<.001	.007	3	5
GBM	SLC7A7 →	+0.558	+0.123	<.001	.001	3	5
LUAD	FCMR →	+0.490	+0.120	.001	.005	3	5
HNSC	ZNF664 →	-0.486	-0.119	.005	.004	3	5
GBM	RCSD1 →	+0.477	+0.110	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009128 vs CARD6 — GBM

Explore this scatter interactively →