Purine nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLIT3, PRDM8, and ZSCAN31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate catabolic process activity versus SLIT3 in OESOPHAGUS (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLIT3 →	-2.514	-1.398	<.001	<.001	3	4
LUNG_SCLC	PRDM8 →	+2.320	+0.706	<.001	.009	3	4
LUNG_SCLC	ZSCAN31 →	-1.907	-0.826	.003	.007	3	4
LARGE_INTESTINE	COX7C →	+0.655	+0.931	<.001	<.001	3	3
LARGE_INTESTINE	SLC2A3 →	-3.681	-0.988	.002	.004	3	3
SOFT_TISSUE	EPB41L5 →	-2.545	-2.007	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009128 vs SLIT3 — OESOPHAGUS

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