Purine nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPRT1, DNPH1, and PNP, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate catabolic process activity versus HPRT1 in OVARY (Pearson r = 0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HPRT1 →	+1.868	+1.402	<.001	<.001	3	13
LUNG_SCLC	DNPH1 →	+1.696	+1.057	<.001	<.001	3	11
BREAST	PNP →	+1.736	+0.744	<.001	<.001	3	10
LARGE_INTESTINE	PSMA2 →	+0.874	+1.235	.001	<.001	3	10
LIVER	CLIC1 →	+2.057	+1.583	<.001	.007	2	10
LARGE_INTESTINE	TUBA4B →	+1.683	+1.269	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009128 vs HPRT1 — OVARY

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