Purine nucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLG3, MAP7, and CRACR2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DLG3 grouped by Purine nucleoside monophosphate biosynthetic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DLG3 →	+2.185	+0.836	.002	.006	3	6
OVARY	MAP7 →	+2.161	+1.123	.001	.003	3	5
LUNG_NSCLC_LUSC	CRACR2A →	+4.158	+0.375	<.001	<.001	3	4
LUNG_NSCLC_LUSC	AGR2 →	+6.164	+0.366	.001	.006	3	4
OESOPHAGUS	FAM174B →	+1.722	+0.309	.001	.002	3	4
LUNG_NSCLC_LUSC	C2CD4D →	+0.355	+0.308	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DLG3 by Purine nucleoside monophosphate biosynthetic process activity — STOMACH

Explore this box plot interactively →