Purine nucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPAT, C1QBP, and RNF126, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate biosynthetic process activity versus PPAT in LUNG_SCLC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PPAT →	+1.034	+0.448	<.001	<.001	3	8
LUNG_SCLC	C1QBP →	+0.908	+0.314	.008	.003	2	8
STOMACH	RNF126 →	+1.125	+0.616	.002	<.001	3	7
STOMACH	ATP5F1D →	+1.247	+0.553	.002	.002	3	7
URINARY_TRACT	ADAM8 →	-5.190	-2.216	<.001	.003	3	7
LIVER	HNRNPA1 →	+0.687	+0.394	.008	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009127 vs PPAT — LUNG_SCLC

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