Purine nucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTD, ZNF419, and BRD8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate metabolic process activity versus BTD in GBM (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	BTD →	-0.323	-0.107	.001	<.001	3	5
UCEC	ZNF419 →	-0.573	-0.200	<.001	<.001	3	4
GBM	BRD8 →	-0.286	-0.120	<.001	<.001	3	4
GBM	ORC4 →	-0.244	-0.091	.004	<.001	3	4
BRCA	PGBD1 →	-0.474	-0.146	.003	.002	3	4
GBM	ZNF776 →	-0.388	-0.119	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009126 vs BTD — GBM

Explore this scatter interactively →