Purine nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB44, METTL8, and PTCD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB44 grouped by Purine nucleoside monophosphate metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ZBTB44 →	-0.921	-0.308	<.001	.001	3	4
SOFT_TISSUE	METTL8 →	-0.798	-0.769	.009	.004	3	4
URINARY_TRACT	PTCD2 →	-0.491	-0.955	.009	.008	3	4
LUNG_SCLC	IL1RN →	+0.053	+0.260	<.001	.002	3	4
OVARY	TCF7L1 →	-1.496	-0.914	.001	.004	3	4
STOMACH	TMEM87B →	+1.393	+0.485	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB44 by Purine nucleoside monophosphate metabolic process activity — LIVER

Explore this box plot interactively →