Purine nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC43A1, MRPL16, and KRT18, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside monophosphate metabolic process activity versus SLC43A1 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SLC43A1 →	+3.345	+0.411	<.001	.004	3	6
SKIN	MRPL16 →	+0.548	+0.202	<.001	.005	3	6
LUNG_SCLC	KRT18 →	-4.630	-0.347	<.001	.005	3	6
LUNG_SCLC	NEIL2 →	+1.419	+0.292	.002	.004	3	6
OVARY	EXOSC9 →	+0.841	+0.322	.001	<.001	3	6
LUNG_NSCLC_LUAD	PTRH2 →	+0.730	+0.236	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009126 vs SLC43A1 — STOMACH

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