Nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA3, ORAI1, and DYNC2LI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDA3 grouped by Nucleoside monophosphate catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PHLDA3 →	-2.120	-1.005	<.001	.001	3	4
BONE	ORAI1 →	-0.669	-1.441	.003	.001	3	4
OVARY	DYNC2LI1 →	-0.617	-0.746	.005	.003	3	4
STOMACH	TK1 →	+0.903	+0.831	.007	.002	3	4
URINARY_TRACT	BLOC1S6 →	+0.472	+1.655	.006	<.001	3	3
URINARY_TRACT	BTN2A1 →	+0.972	+1.658	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDA3 by Nucleoside monophosphate catabolic process activity — BREAST

Explore this box plot interactively →