Nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT4, AVPI1, and MYL9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate catabolic process activity versus B4GALT4 in OESOPHAGUS (Pearson r = -0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	B4GALT4 →	-0.896	-0.798	.006	.002	3	5
BLOOD_Myeloma	AVPI1 →	-0.645	-0.509	.002	<.001	3	4
LARGE_INTESTINE	MYL9 →	-1.844	-0.573	.007	.003	3	4
LARGE_INTESTINE	VSIR →	-1.209	-0.769	.004	<.001	3	4
LARGE_INTESTINE	GLS →	-0.886	-0.846	.002	.004	3	4
LARGE_INTESTINE	ITGB5 →	-0.962	-0.740	.007	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009125 vs B4GALT4 — OESOPHAGUS

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