Nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside monophosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPRT1, MAT2B, and PGK1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate catabolic process activity versus HPRT1 in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HPRT1 →	+1.587	+0.502	<.001	.006	3	10
LARGE_INTESTINE	MAT2B →	+1.503	+1.087	<.001	<.001	3	8
LARGE_INTESTINE	PGK1 →	+1.940	+1.150	<.001	<.001	3	8
LARGE_INTESTINE	NME1 →	+1.664	+1.094	<.001	<.001	3	7
LARGE_INTESTINE	ENO1 →	+2.027	+1.070	<.001	<.001	3	7
LARGE_INTESTINE	RPS20 →	+1.130	+0.889	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009125 vs HPRT1 — LUNG_SCLC

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