Nucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FANCA, PFAS, and NPM1P9, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate biosynthetic process activity versus FANCA in ACC (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	FANCA →	+0.875	+0.036	<.001	<.001	3	29
UCS	PFAS →	+1.267	+0.055	<.001	<.001	2	29
LAML	NPM1P9 →	+0.524	+0.043	<.001	<.001	3	28
ACC	CENPI →	+0.818	+0.041	<.001	<.001	3	28
UVM	PPAT →	+1.168	+0.042	<.001	<.001	3	28
ACC	TICRR →	+1.245	+0.062	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009124 vs FANCA — ACC

Explore this scatter interactively →