Nucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside monophosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EEF1D_S162, SCAMP1, and WWTR1_S89, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate biosynthetic process activity versus EEF1D_S162 in OV (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EEF1D_S162 →	+1.623	+0.238	<.001	<.001	3	4
BRCA	SCAMP1 →	-0.392	-0.146	<.001	.004	3	3
UCEC	WWTR1_S89 →	+1.004	+0.339	<.001	<.001	3	3
GBM	HAUS2 →	+0.350	+0.177	.001	<.001	3	3
UCEC	LARP1B_S60 →	+0.528	+0.240	<.001	<.001	3	3
UCEC	MCM4_S131 →	+0.965	+0.339	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009124 vs EEF1D_S162 — OV

Explore this scatter interactively →