Nucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside monophosphate biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHX8, CCND1, and MPHOSPH6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHX8 grouped by Nucleoside monophosphate biosynthetic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DHX8 →	+0.369	+0.063	.001	<.001	3	5
BONE	CCND1 →	-0.924	-0.115	.008	.002	2	6
BONE	MPHOSPH6 →	+0.370	+0.124	.007	.008	3	5
LIVER	FUT6 →	+0.261	+0.079	.009	.006	3	4
STOMACH	PPP3CA →	+0.161	+0.078	.003	.001	3	4
STOMACH	GPR32 →	+0.218	+0.072	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHX8 by Nucleoside monophosphate biosynthetic process activity — KIDNEY

Explore this box plot interactively →