Nucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FCER1G, PARVG, and MNDA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate metabolic process activity versus FCER1G in OV (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FCER1G →	+0.486	+0.024	<.001	.001	3	7
GBM	PARVG →	+0.551	+0.031	.004	.002	3	7
OV	MNDA →	+0.808	+0.032	.002	.004	3	6
GBM	MX2 →	+0.514	+0.027	.001	<.001	3	6
LUAD	PARP14 →	+0.245	+0.025	<.001	.003	3	6
OV	PLAU →	+0.833	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009123 vs FCER1G — OV

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