Nucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR84, PDCD1LG2, and BCL2A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate metabolic process activity versus GPR84 in LUAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GPR84 →	+0.668	+0.081	<.001	.001	3	5
BRCA	PDCD1LG2 →	+0.562	+0.110	<.001	.004	3	5
OV	BCL2A1 →	+1.105	+0.150	.001	.008	3	5
OV	MARCO →	+1.783	+0.190	<.001	.002	3	5
COAD	CXCL8 →	+1.068	+0.158	.004	<.001	3	5
COAD	IL1B →	+0.895	+0.154	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009123 vs GPR84 — LUAD

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