Nucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF2, LSM12, and MYC, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside monophosphate metabolic process activity versus EEF2 in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EEF2 →	+1.208	+0.419	.001	.002	3	8
PANCREAS	LSM12 →	+0.847	+0.351	<.001	<.001	3	7
BONE	MYC →	+2.719	+0.368	.003	.006	3	7
STOMACH	RNF126 →	+1.269	+0.392	.001	<.001	3	7
STOMACH	HNRNPA1 →	+0.984	+0.406	.008	.004	3	7
URINARY_TRACT	NTHL1 →	+0.651	+0.532	.005	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009123 vs EEF2 — STOMACH

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