Ribonucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGR, INSYN2B, and LILRB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside metabolic process activity versus FGR in UCEC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FGR →	+0.819	+0.186	<.001	<.001	3	7
GBM	INSYN2B →	+0.883	+0.170	<.001	<.001	3	6
UCEC	LILRB2 →	+0.873	+0.184	<.001	.007	3	6
HNSC	WAS →	+0.705	+0.185	<.001	<.001	3	5
UCEC	ZC3H12D →	+0.782	+0.189	<.001	.002	3	5
GBM	SP140 →	+0.662	+0.178	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009119 vs FGR — UCEC

Explore this scatter interactively →