Ribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK10, CSTF1, and ACP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DOCK10 grouped by Ribonucleoside metabolic process-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DOCK10 →	+0.120	+1.155	<.001	.001	3	5
OESOPHAGUS	CSTF1 →	+0.123	+1.261	.001	<.001	3	4
OESOPHAGUS	ACP3 →	-0.395	-1.436	.007	.004	3	4
BLOOD_Lymphoma	SALL2 →	+0.269	+2.259	.006	<.001	3	4
SKIN	KCNK10 →	+0.178	+1.058	<.001	<.001	2	5
BLOOD_Leukemia	CTRL →	-0.156	-1.146	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DOCK10 by Ribonucleoside metabolic process activity — STOMACH

Explore this box plot interactively →