Ribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FN1, ACBD4, and SNRPD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FN1 grouped by Ribonucleoside metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FN1 →	+3.362	+1.164	<.001	.005	3	4
CNS	ACBD4 →	-0.726	-0.866	.003	.002	3	4
URINARY_TRACT	SNRPD1 →	-0.807	-1.357	.009	.007	3	4
BLOOD_Lymphoma	MGME1 →	+0.808	+1.833	<.001	.002	3	4
BLOOD_Myeloma	RAB33A →	+3.407	+1.442	.001	.003	3	4
BONE	GK5 →	+0.888	+1.733	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FN1 by Ribonucleoside metabolic process activity — OESOPHAGUS

Explore this box plot interactively →