Ribonucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS26, PFKFB2, and UHRF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside metabolic process activity versus RPS26 in SKIN (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPS26 →	+0.528	+1.285	<.001	<.001	3	5
STOMACH	PFKFB2 →	-1.581	-1.371	.004	.001	3	5
BLOOD_Leukemia	UHRF1 →	+2.148	+0.318	<.001	<.001	3	4
SKIN	LRP3 →	+1.533	+1.186	<.001	<.001	2	5
SKIN	GTF3C6 →	+0.607	+1.176	.003	<.001	3	4
PANCREAS	MSLN →	-3.137	-1.310	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009119 vs RPS26 — SKIN

Explore this scatter interactively →