Nucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMD9, NMI, and DPYD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside metabolic process activity versus SAMD9 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SAMD9 →	+0.518	+0.023	<.001	<.001	3	6
OV	NMI →	+0.531	+0.050	<.001	<.001	3	6
COAD	DPYD →	+0.448	+0.017	.001	.001	3	6
GBM	UBQLN4 →	-0.246	-0.042	.004	<.001	3	6
HNSC	EEF2_S502 →	-0.583	-0.048	.002	.001	3	5
OV	SRRM1_S431 →	-0.760	-0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009116 vs SAMD9 — BRCA

Explore this scatter interactively →