Nucleoside metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAB1, LCP2, and MYO1F, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside metabolic process activity versus STAB1 in LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	STAB1 →	+0.586	+0.206	.003	.004	3	8
COAD	LCP2 →	+0.638	+0.169	.006	<.001	3	8
BRCA	MYO1F →	+0.772	+0.190	<.001	<.001	3	8
BRCA	FGD2 →	+0.654	+0.170	.001	<.001	3	8
COAD	CYTH4 →	+0.587	+0.168	.005	.001	3	7
BRCA	LAPTM5 →	+0.742	+0.154	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009116 vs STAB1 — LUAD

Explore this scatter interactively →