Nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIGP, UHRF2, and YWHAZ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PIGP grouped by Nucleoside metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PIGP →	-0.901	-1.340	<.001	<.001	3	4
SOFT_TISSUE	UHRF2 →	+1.102	+1.393	.002	.006	3	4
BONE	YWHAZ →	+0.927	+1.364	.002	.003	2	4
URINARY_TRACT	COPS4 →	+0.964	+1.786	.003	<.001	3	3
URINARY_TRACT	RFT1 →	+1.186	+2.108	.004	<.001	3	3
SKIN	NNT →	-0.860	-0.974	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PIGP by Nucleoside metabolic process activity — OESOPHAGUS

Explore this box plot interactively →