Nucleoside metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NTHL1, ERP44, and PAQR4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside metabolic process activity versus NTHL1 in BLOOD_Leukemia (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NTHL1 →	+0.795	+0.170	<.001	.001	3	6
URINARY_TRACT	ERP44 →	-0.729	-0.359	.008	.009	3	5
BLOOD_Leukemia	PAQR4 →	+1.132	+0.201	<.001	.006	3	5
BLOOD_Leukemia	ANKRD13B →	+0.928	+0.235	<.001	<.001	3	5
STOMACH	RPS2 →	+0.972	+0.229	.001	<.001	3	5
LUNG_NSCLC_LUAD	COL4A2 →	-2.878	-0.569	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009116 vs NTHL1 — BLOOD_Leukemia

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