Purine nucleobase biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine nucleobase biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MCM2_S139, NASP, and RRP36_S73, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleobase biosynthetic process activity versus MCM2_S139 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MCM2_S139 →	+0.651	+0.045	<.001	.001	3	9
BRCA	NASP →	+0.418	+0.042	<.001	<.001	3	9
LUAD	RRP36_S73 →	+0.666	+0.054	<.001	<.001	3	8
BRCA	MAD2L1 →	+0.466	+0.042	<.001	.001	3	8
LUAD	MCM4 →	+0.496	+0.055	<.001	<.001	3	8
BRCA	MCM5 →	+0.726	+0.069	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009113 vs MCM2_S139 — BRCA

Explore this scatter interactively →