Purine nucleobase biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine nucleobase biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAVIN1, GSKIP, and ITPK1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CAVIN1 grouped by Purine nucleobase biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CAVIN1 →	-3.562	-0.821	.005	.009	3	5
BONE	GSKIP →	+0.652	+1.087	.006	.006	3	5
LUNG_SCLC	ITPK1 →	+1.018	+1.146	.001	<.001	3	4
STOMACH	PCNP →	+0.541	+1.236	<.001	.001	3	4
BREAST	ZNF518A →	+0.846	+0.908	.006	.005	3	4
STOMACH	CMTM3 →	-3.130	-0.939	.002	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAVIN1 by Purine nucleobase biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →