Nucleobase metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleobase metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPC24, SHOC2, and MCM2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase metabolic process activity versus SPC24 in LSCC (Pearson r = 0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPC24 →	+0.648	+0.077	<.001	<.001	3	7
HNSC	SHOC2 →	-0.203	-0.081	<.001	<.001	3	7
BRCA	MCM2 →	+0.562	+0.042	<.001	<.001	3	7
BRCA	MCM5 →	+0.556	+0.038	.001	<.001	3	7
BRCA	CTPS1 →	+0.377	+0.029	.001	<.001	3	6
LUAD	MCM6_S762 →	+1.191	+0.037	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009112 vs SPC24 — LSCC

Explore this scatter interactively →