Nucleobase metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRTFDC1, PHGDH, and PAQR4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase metabolic process activity versus PRTFDC1 in OV (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRTFDC1 →	+0.950	+0.179	<.001	<.001	3	5
OV	PHGDH →	+0.687	+0.124	.002	.003	3	5
HNSC	PAQR4 →	+0.861	+0.146	<.001	<.001	3	5
LUAD	NXPH4 →	+0.928	+0.114	.001	.003	3	4
LUAD	H4C11 →	+0.523	+0.114	.006	.003	3	4
COAD	KIAA1549L →	+0.533	+0.154	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009112 vs PRTFDC1 — OV

Explore this scatter interactively →