Nucleobase metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleobase metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDA, NEURL4, and KLF16, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleobase metabolic process activity versus CDA in LARGE_INTESTINE (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDA →	-2.188	-0.398	<.001	.001	3	7
BLOOD_Leukemia	NEURL4 →	+0.728	+0.205	<.001	<.001	3	5
OVARY	KLF16 →	+1.033	+0.416	.001	.001	3	5
BONE	SDC4 →	-2.746	-0.308	<.001	.002	3	5
BLOOD_Leukemia	ANXA2 →	-1.371	-0.207	.001	<.001	3	5
BLOOD_Leukemia	DNAJC15 →	-1.241	-0.168	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009112 vs CDA — LARGE_INTESTINE

Explore this scatter interactively →