Vitamin catabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEX11B, ANKRD1, and FAM210A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEX11B grouped by Vitamin catabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PEX11B →	-0.990	-1.075	<.001	<.001	3	5
BREAST	ANKRD1 →	+1.317	+0.580	<.001	.005	3	4
BREAST	FAM210A →	+0.889	+0.824	<.001	<.001	3	4
BREAST	PTPN18 →	-0.761	-0.711	.002	.008	3	4
LIVER	NDC80 →	+1.681	+1.386	<.001	.008	3	3
BREAST	FBXW4 →	-0.784	-0.787	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEX11B by Vitamin catabolic process activity — BREAST

Explore this box plot interactively →