Vitamin catabolic process

Across TCGA cell cohorts, RNA activity of the Vitamin catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERV3-1, ZNF117, and HOOK2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin catabolic process activity versus ERV3-1 in OVARY (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ERV3-1 →	-1.160	-0.153	.002	<.001	3	11
LUNG_NSCLC_LUAD	ZNF117 →	-1.222	-0.164	<.001	<.001	3	8
URINARY_TRACT	HOOK2 →	-1.224	-0.192	.006	<.001	2	9
OVARY	CARF →	-0.942	-0.181	<.001	<.001	3	8
BLOOD_Lymphoma	CMTR2 →	-0.629	-0.139	<.001	<.001	3	8
SOFT_TISSUE	ACAD10 →	-0.638	-0.184	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009111 vs ERV3-1 — OVARY

Explore this scatter interactively →